What is Soil pH and Why is it important in farming? - Chemosmart

            Viral infections may promote Alzheimer's like diseases

             According to study, there are many different types of viral diseases may contribute to neurodegenerative diseases like Alzheimer's and Parkinson's. This research paper are published on the basis of laboratory experiments. This experiments showed that viral molecules facilitate intercellular spreading of proteins. This proteins is known as Prison disease which have the capacity to pass from one cell to other cell, where they transfer their abnormal shape to proteins of the equal or same type. And hence the disease spreads to the Human brain. Scientists have been speculating how an acute viral dispute might lead to conscious neurological disorders years. 

             All above phenomenon are present in Alzheimer's and Parkinson's disease. This both diseases shows assemblies of misfolded proteins. Researchers said thank Transmission of aggregates could contains direct cell to cell contact, the release of "naked" aggregates into extracellular packaging in vesicles. Vesicles are the small bubbles surrounded for contact or communication between the two cells. 

  

                 Ina Vorberg which are the professor at the University of Bonn said that- The precise mechanisms of transmission are unknown. However, they are obvious guess, that aggregate exchange by two direct cell communication and via vesicles dependent on ligand-receptor interaction. The scientists require that is cause of in two scenarios, membranes require to produce contact and fuse. 

This is impressed when Ligands are present that bind to receptors on the place of the cell and then cause the both membranes to fuse. 

          Researchers shows an larage series of studies with different cell cultures. The proposed the intercellular move of either aggregates of tau proteins, as they present in same form in Alzheimer's disease. The researchers disrupt cells to make viral proteins which mediate target cell binding and membrane fusion.

         Let us consider the example- SARS- COV-2 spike protein S which stems from the virus causing Covid-19. And Vesicular stomatitis virus Glycoprotein VSV-G which present in a pathogen which causes cattles and other many different animals infection. 

            The Vorberg said that - we could prove that the viral proteins which are incorporated both into the cellular membrane and the extracellular vesicles. As presence of their availability increased protein aggregate spreading around cells, two by direct cell communication or by extracellular vesicles. The viral ligands mediated an effective movement of aggregates into recipient cells, where they induced new aggregates. The ligands unlock the recipient cells. 

            Vorberg also said that- probably our cellular report do not replicate the many aspects of the brain with its very specialized cell types. However, independent of the tested cell kind making the pathogenic aggregates, the presence of affected or viral ligands purely increased the spreading of misfolded proteins to the another cells. The brains suffering from neurodegenerative diseases of patients contains certain viruses. They cause inflammation and having a dangerous effect. And hence Accerlating Neurodegeneration.The affected proteins could also treat unusual. They could growing intercellular expanding of protein aggregates before already ongoing in neurodegenerative diseases like Alzheimer's. 

            Above all research published in Nature Communications proves that how specific chemicals affected on virus surfaces might increase the aggregation of dangerous proteins joined to illness as Alzheimer's and Parkinson's.